L-ornithine is a basic amino acid and is important in the formation of urea. It is a nonprotein amino acid which means that it does not
occur in proteins. The body uses it in the biosynthesis of L-arginine, L-proline and polyamines.
L-Ornithine may be very helpful if you are trying to lose fat. It is important because it initiates the release of growth hormone in the body.
This can be very helpful with fat metabolism.
The liver and immune system require ornithine to function properly. It assists in ammonia detoxification. Athletes may also benefit from this nutrient.
Some people combine L-ornithine with similar doses of L-arginine.
L-Ornithine increases tissue levels of glutamine and arginine, both of which are
known to increase growth hormone levels and regulate protein synthesis. Ornithine Alpha-Ketoglutarate
works by encouraging the secretion of insulin and growth hormone. This results in increased levels of IGF-1
and growth hormone levels within the user. As a result Ornithine Alpha-Ketoglutarate an excellent supplement
for athletes looking to increase muscle mass, growth hormone levels and strength.
Supplementing with Ornithine-Alpha ketoglutarate also decreases muscle catabolism (breakdown) and promotes healing of wounds.
The concepts of energy dysregulation and oxidative stress and their complicated interdependence have rapidly
evolved to assume primary importance in understanding the pathophysiology of numerous neurological disorders.
Therefore, neuroprotective strategies addressing specific bioenergetic defects hold particular promise in the
treatment of these conditions (i.e., amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease,
Friedreich’s ataxia, mitochondrial cytopathies and other neuromuscular diseases), all of which, to some extent,
share ‘the final common pathway’ leading to cell death through either necrosis or apoptosis.
Compounds such as creatine monohydrate and coenzyme Q10 offer substantial neuroprotection against ischaemia, trauma, oxidative
damage and neurotoxins. Miscellaneous agents, including a-lipoic acid, ß-OH-ß-methylbutyrate, riboflavin and
nicotinamide, have also been shown to improve various metabolic parameters in brain and/or muscle. This review
will highlight the biological function of each of the above mentioned compounds followed by a discussion of
their utility in animal models and human neurological disease. The balance of this work will be comprised of
discussions on the therapeutic applications of creatine and coenzyme Q10.
